Can we treat chronic pain syndrome with low dose naltrexone

A Chronic pain syndrome is a normal reaction of your body to an affliction or ailment, a signal that something is amiss. When your body recovers, it normally stops aching.

But for several people, the pain persists even after its reason is gone. When it persists for more than 3 months, it’s termed chronic pain. When you feel pain day after day, it could affect your mental and physical health.

Approximately 25% of people experiencing chronic pain would turn into a condition named chronic pain syndrome (CPS). That is when people develop symptoms exceeding pain, such as depression and anxiety, which might hinder their everyday lives.

CPS can be difficult to manage, but it’s not impracticable. A blend of treatments including counseling, relaxation procedures, and physical therapy can help alleviate your pain and the different symptoms that it brings.

How is Chronic Pain Syndrome caused?

Doctors don’t comprehend specifically what induces CPS. It usually begins with an impairment or painful ailment such as:

  • Arthritis and different joint problems
  • Headaches
  • Back pain
  • Muscle strains and sprains
  • Repeated stress injuries
  • Fibromyalgia
  • Lyme disease
  • Nerve damage
  • Cancer
  • Broken bones
  • Acid reflux or ulcers
  • Irritable bowel syndrome (IBS)
  • Inflammatory bowel disease (IBD)
  • Endometriosis, in which the tissue in the uterus grows outside
  • Operation


The causes of CPS comprise both physical and mental circumstances. Some specialists think that people undergoing the condition produce a problem in their system of nerves and glands that are used by the body to manage stress. This makes them perceive pain differently.

Different experts state CPS is a developed response. When you’re experiencing pain, you might begin to repeat specific bad habits, even when the pain has left or has decreased.

CPS can influence people of all age groups and both genders, but it’s prevalent in women. Individuals with major depression and different mental health conditions are also likely to receive CPS.

Chronic Pain Symptoms:

Chronic pain influences your physical well-being, your sentiments, and also your life eventually. The discomfort can give rise to additional symptoms, like:

  • Depression
  • Anxiety
  • Poor sleep
  • Irritability
  • Feeling very tired
  • Guilt
  • Lack of interest in sex
  • Drug/alcohol abuse
  • Marriage or family difficulties
  • Job loss

Some people with CPS require to take more and more medication to control their pain, and this makes these people dependent on those drugs.

Treatment for chronic pain syndrome:

Chronic pain proves to be mystifying, but it can be treated.

Some choices include:


  • Medications to relieve pain. These comprise anti-inflammatories, muscle relaxers, steroids, antidepressants, and other medicines that have pain-relieving properties, and, in critical cases, opioids.
  • Physical therapy to improve extensibility and range of motion.
  • Nerve blocks obstruct pain signals.
  • Psychological/behavioral therapy. While they might not produce a huge influence on pain, some emotional therapies can produce a convincing impact on mood. For instance, cognitive behavior therapy – a kind of speech therapy that encourages you to reframe negative thinking – has proved to be useful in boosting mood, almost up to a year following the end of treatment. In a different study, biofeedback was helpful in decreasing muscle tension and helping to cope with chronic pain. Biofeedback is a sort of treatment that guides you to handle your mind to manage bodily responses, such as rapid breathing.

Chronic pain syndrome treatment with LDN

As the medical community seeks to create a huge U-turn following two destructive decades of promoting long-term opioid usage for constant pain, experts have been striving to produce safe, effective options.

When naltrexone is applied to manage dependence in the form pill, it’s given at 50 mg, however, chronic pain patients say it eases their pain at dosages smaller than 1/10th of that.

Low-dose naltrexone has remained hidden for years on the edges of medicine, though its enthusiastic advocates despair that it might stay stuck there. Naltrexone, as it can be manufactured generically, isn’t yet manufactured at the moderate doses that appear to be most suitable for pain patients.

Some of the boosts regarding low-dose naltrexone have covered some rather outrageous claims with an insufficient investigation to back them, such as applying it to treat neuropathic pain and multiple sclerosis or also administering it as a weight-loss medication.

In the previous two years, though, there’s been a significant improvement in current studies issued on low-dose naltrexone, numerous backing its applications as a treatment for chronic pain, though a maximum of those were yet small pilot investigations.

Other options

  • Acupuncture: According to an interpretation of studies, acupuncture decreased pain levels in 50% of patients who sought it, as compared to a 30% pain decline in people who did not take acupuncture.
  • Yoga: Because it supports loosening muscles, promotes deep, corrective breathing, and improves mindfulness, yoga can be helpful in subduing the depression and anxiety that occurs with chronic pain, therefore increasing your quality of life.

His main line of investigation at that point was HIV/AIDS and, the main target was to increase the rate of survival of severely immune-compromised patients.

Following the next 30 years, Dr. Ian Zagon excelled in the primary investigation into endorphins and Low Dose Naltrexone. He issued almost 300 writings on the topic and it was reinforced, without any uncertainty, that the opiate/endorphin receptor system is required in practically all the biological systems that control the immune response.

How LDN Manages Pain Explanation

It was discovered that lower doses of naltrexone, about 1/10th of those utilized for opiate addiction, produce helpful influences on people experiencing various autoimmune disorders.

For chronic pain sufferers, the central nervous system becomes flooded with out of control pain signals and overflow the body’s normal pain-relieving systems. Short-term blocking of the opiate receptors provokes the human body to overexpress endogenous opioids and receptors. This rebound impact replaces stability in the opioid system.

The primary purpose of low-dose naltrexone is to reduce or stop the progress of the condition. When Low Dose Naltrexone brings the immune system back to normal, it prevents the additional succession of autoimmune disease, alleviating soreness, pain, and consequently stress, which usually gives rise to aggravations of an extensive range of autoimmune conditions. Apart from greater pain management, advantages obtained from the application of LDN involve reduced fatigue, enhanced mood, decreased sleep disturbances, and improved cognitive capacity.

Clinical trials and Studies

There are several clinical trials that support the use of low-dose naltrexone for treating autoimmune conditions, including Sjogren’s Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Complex Regional Pain Syndrome (CRPS), Neuropathic Corneal Pain, including LDN for Cancer. The number of diseases that have gained benefit from LDN is high, but a maximum of them are the outcome of only one element, which is a dysfunctional immune system.

Sjogren’s Syndrome

It is a persistent autoimmune disorder that induces inflammation in the salivary and lacrimal glands resulting in dry mouth and eyes accompanied by exhaustion and musculoskeletal ache. Scott Zashin conducted a case study that describes a 47-YO woman who experienced no cure on standard treatment for almost 5-years since diagnosis, shifted to Low Dose Naltrexone. After a few alterations in her doses in some time, the patient observed notable improvement in her pain and fatigue. While her manifestations got better, the most intriguing thing regarding the case was her clinical improvement in inflammatory markers.

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