Managing chronic pain with low dose naltrexone (LDN)


Low dose naltrexone is significantly known to treat chronic pain in people. It acts in a way that relieves the pain-generating nerves by improving the autoimmune conditions in the nervous system. The human nervous system consists of nerves and cells that are known as glia. The glial cells are responsible to provide immune protection and defend the central nervous system. The glia cells are made up of astrocytes and microglia and either of them has a specific role. The astrocytes are known for maintaining the balance of cell fluid that is significant for the chemical reactions taking place inside the cells. The microglia act as a guard and protect the immune system.

The glia remains inactive when the conditions are normal but go into an active state in response to an injury or infection. During any circumstances of trauma, injury, opioids, or injury, the brain, and spinal cord gets inflamed, which is usually a sign of activation of glial cells. The low-dose naltrexone drug that helps to block the effect of opioids also blocks the activation of the glial cells that in turn helps to manage chronic pain. The researches have shown that LDN has effectively treated chronic nerve pain conditions such as written below:

Complex regional pain syndrome

Complex regional pain syndrome (CRPS) is a type of chronic neurological pain that generally disturbs the arm or leg. CRPS is a not-so-common condition and its causes are not so clear. This condition is known to develop after an incident such as surgery, injury, heart attack, or a stroke. The symptoms of CRPS include:

  • Stinging pain in arm, leg, hand, or foot.
  • Sensitive to cold or hot touch
  • Inflammation of the affected area
  • Decreased movement in the affected area
  • Variations in skin color
  • Imbalanced skin temperature
  • Variation in skin texture
  • Changes in the growth of hair and nails
  • Inflammation and damage of joints
  • Sudden muscle spasms
  • Weakness of muscles
  • Muscular atrophy

The possible causes of Complex regional pain syndrome (CRPS) are quite unclear. It is considered that an injury or abnormality of the central and peripheral nervous systems causes CRPS. Type 1 CRPS, also known as reflex sympathetic dystrophy (RSD), occurs due to an injury or trauma to your limb and not your nerves directly. On the other hand, type 2 CRPS, also known as causalgia, occurs due to some kind of injury to your nerves directly.

Reflex sympathetic dystrophy (RSD)

Reflex sympathetic dystrophy (RSD) is type 2 of the Complex Regional Pain Syndrome (CRPS). In this condition, chronic pain is triggered by an injury or trauma to the tissue and no damage to the nerve. RSD is very uncommon as it affects the bones, blood vessels, nerves, skin, and muscles at the very same time.

The symptoms of Reflex sympathetic dystrophy (RSD) are the same as the Complex Regional Pain Syndrome (CRPS). Both these chronic conditions are characterized by intense stinging pain in the affected area, excessive sweating, changes in the bone and skin, temperature sensitivity, etc.

The causes of Reflex sympathetic dystrophy (RSD) are not known just as Complex Regional Pain Syndrome (CRPS). But it is considered that the condition is caused due to the dysfunction of the sympathetic nervous system. It is quite understandable that RSD is triggered by extreme trauma such as fractures, sprains, surgeries, damage to nerves or blood vessels, or brain injuries.

Diabetic peripheral neuropathy

Diabetic peripheral neuropathy is a form of damage to the nervous system that occurs in case you are a patient of diabetes. High levels of blood sugar can end up injuring the nerves throughout your body. It causes damage to the nerves in the legs and feet most commonly.

The symptoms of Diabetic peripheral neuropathy are written below:

  • sharp pain in your legs and feet
  • A feeling of numbness in affected areas
  • problems with the digesting food
  • problems with the urinary tract
  • heart problems

The exact cause of Diabetic peripheral neuropathy is unknown. But according to the researchers, its main cause is uncontrolled high blood sugar levels. High blood sugar causes damage to nerves. It also weakens the blood vessels.

Working of LDN in managing chronic pain

We should understand that low-dose naltrexone does not work as soon as it is taken. It may require from a few days to many months to make a difference. It is widely known to produce an effective response. The basic role of LDN in managing chronic pain is to slow down the progress of the disease. And it may continue to improve symptoms, relieve your pain, reduce depression and tension, improve stress levels, and hence create a feeling of wellbeing.

LDN from Compounding Pharmacy

Those of you who are planning to shift to the low dose naltrexone from the traditional medications can visit the harbor compounding pharmacy. The harbor compounding pharmacy manufactures low-dose naltrexone in a variety of forms. Also, they give you the option to get the medications customized according to your needs. You just have to provide your prescription to the harbor compounding pharmacy and leave the rest upon them. Hence it is far better than the conventional pharmacies as they would not cater to our needs specifically.

If you have any queries related to the drug or your health condition, you can also contact and get recommendations from the doctors that the harbor compounding pharmacy has on its panel.

For more details, feel free to visit the website of harbor compounding pharmacy.

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